Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks

Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks

While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causi...

P 59: Non-Steroidal Anti-Inflammatory Drugs as a Prevention of Alzheimer Disease: Risks and Benefits

Alzheimer's disease (AD) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. The exact cause of Alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. This brings in mind using non-steroidal anti-inflammatory drugs (NSAID) as treatment or prevention of the disease. ...

Non-steroidal anti-inflammatory drugs.

Cardiovascular complications of non-steroidal anti-inflammatory drugs.

Coxibs, such as rofecoxib, celecoxib, and valdecoxib, selectively inhibit cyclooxygenase (COX)-2, the mainly inducible, pro-inflammatory COX isoform. Unlike traditional non-steroidal anti-inflammatory drugs (NSAIDs) most coxibs do not significantly inhibit COX-1 and are therefore less toxic to the gastrointestinal tract. Hence, coxibs widely replaced traditional NSAIDs for treatment of arthriti...

Pnm-24: Pharmacologic Effect of Non-Steroidal Anti-Inflammatory Drugs in Reproductive System-(An Experimental Design

Background: Some patients that used Non-steroidal anti-inflammatory drug for a long time, as an analgesic, antipyretic or anti-inflammatory agent may be seen unusual effect of this drug on spermatogenesis and the level of blood testosterone hormone. The aim of this research is assess the effect of this drug on male-reproductive system functions Materials and Methods: This experimental research ...